That doesn't seem right/helpful as data import. I think what I would do is strip all trailing periods and commas, and then set newItem.title = [no title] when there's nothing left -- does that sound right?

What you suggest looks fine for me.

I suggest to split this further up, because maybe also trialTitle for a case might exitsts which is not all uppercase:

if (newItem.itemType == "case" && trialTitle) {
   if (trialTitle == trialTitle.toUpperCase()) {
      newItem.title = ZU.capitalizeTitle(trialTitle, true);
   } else {
      newItem.title = trialTitle;
   }
}